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On the following day, samples were changed into fresh culture media containing peroxynitrite (Cayman, 81565) alone for 24 or 48 h, or with the following drugs for 48 h as indicated in the text: ebselen (30 μM, Sigma-Aldrich, E3520)

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Thyroid microenvironment has a high antioxidant metabolic profile at baseline due to inherently high intracellular ROS levels utilized for thyroid hormonogenesis